a(CHEBI:"amyloid-beta") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")

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PubMed:19293145

Similar effects of Abeta on nAChR expression have been confirmed in studies using cultured cells; Abeta causes a reduced expression of nAChRs in PC12 cells (Guan et al., 2001), and alpha4, alpha3, and alpha7 expression are all increased in cultured rat astrocytes (Xiu et al., 2005).

Related Edges 3

• a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA7)
• a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA4)
• a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA3)

Experimental Factor Ontology (EFO)

PC12

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