a(CHEBI:nicotine) causesNoChange a(MESH:Manduca)

PubMed:19126755

One insect has escaped the ill effects of nicotine, Manduca sextans or the tobacco horn worm. While nicotine binds the nAChR to activate and subsequently desensitize it, this insect eats the tobacco plant without ill effects. Manduca exhibits two adaptations to tolerate the effects of nicotine. The first is altered nAChR amino acid sequences that limit the affinity of nicotine for the nAChR (136). The second is the development of the functional equivalent to a blood-brain barrier.

Related Edges 3

• a(MESH:Manduca) association bp(GO:"establishment of blood-brain barrier")
• bp(GO:"establishment of blood-brain barrier") association a(MESH:Manduca)
• p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases bp(GO:"response to nicotine")

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