complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases a(HBP:"Tau aggregates")

PubMed:29311797

Contrary to the neuroprotective effects of CyP40, two FK506- binding proteins (FKBPs) have been shown to stimulate toxic tau aggregation (Blair et al., 2013; Giustiniani et al., 2015; Kamah et al., 2016). One of these, FKBP51, coordinates with Hsp90 to preserve toxic tau oligomers in vivo (Blair et al., 2013).

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