act(p(HGNC:GAL)) causesNoChange a(HBP:"Tau MN423")

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PubMed:18986241

CBF neurons displaying the tau C3 epitope, a marker for early stage NFT formation, were often hyperinnervated by GAL-containing fibers, whereas CBF neurons displaying the tau epitope MN423, an end-stage NFT marker, were not associated with GAL. Single cell gene expression studies have demonstrated that the levels of mRNAs encoding select subclasses of PP1 subunits (e.g., PP1alpha and PP1gamma) are stable in GAL hyperinnervated but downregulated in non-hyperinnervated CBF neurons in AD [149]

Related Edges 3

• a(HBP:"Tau C3") biomarkerFor path(MESH:D059329)
• act(p(HGNC:GAL)) increases r(HGNC:PPP1CA)
• act(p(HGNC:GAL)) increases r(HGNC:PPP1CC)

Disease Ontology (DO)

Alzheimer's disease

MeSH

Cholinergic Neurons

MeSH

Cognitive Dysfunction

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