bp(GO:autophagy) increases deg(a(HBP:"protein aggregates"))

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PubMed:29758300

Although the UPS is accountable for the degradation of up to 80–90% of proteins, misfolded proteins and aggregates are too large to be processed through the proteasome barrel and can impede UPS function by physical occlusion, leaving autophagic-lysosomal breakdown as the only effective pathway to clear these proteins [25,26]

Related Edges 1

• bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(HBP:misfolding)))

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