composite(a(CHEBI:simvastatin), p(MGI:App, frag("25_35"))) increases bp(GO:memory)

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PubMed:25514383

In a study conducted by Zhi et al. (2014), this molecule was used to treat a mouse model obtained with injections of the peptide Aß25-35. Administration for 11 days of SV improved memory performance in the Morris water maze task and promoted survival of CA1 pyramidal cells. This effect was proposed to be promoted by alpha7 nAChRs, since it is blocked by MLA administration (Zhi et al., 2014)

Related Edges 5

• a(CHEBI:simvastatin) decreases bp(GO:"apoptotic process")
• a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:simvastatin))
• a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:memory)
• a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(GO:"apoptotic process")
• a(PUBCHEM:5311278) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))

MeSH

Alzheimer Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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