a(CHEBI:radicicol) decreases act(p(FPLX:HSP90))

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PubMed:25784053

One strategy is to directly activate HSF1, thereby increasing the expression of multiple molecular chaperones simultaneously. This approach has been traditionally achieved by inhibition of HSP90 with compounds that bind the N-terminal ATP-binding pocket, such as radicicol, geldanamycin, or 17-AAG (64, 132–134).

Related Edges 3

• a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90))
• a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90))
• act(p(FPLX:HSP90)) decreases act(p(HGNC:HSF1))

Cell Ontology (CL)

motor neuron

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