a(HBP:"C-30-27") increases path(MESH:Cognition)

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PubMed:25672970

In this study, we modified the PCAF inhibitor by chemical derivatization and selected compound C-30-27 as the most potent PCAF inhibitor. We demonstrated that C-30-27 selectively inhibited acetylation-dependent nuclear factor-κB (NF-κB) at Lys-122 and suppressed the NF-κB-mediated inflammatory response induced by lipopolysaccharide (LPS) or Aβ in both BV2 and Neuro-2A (N2A) cells. Finally, we demonstrated that C-30-27 improved cognitive deficits, as well as the capacity for locomotion and the damaged cholinergic system in the Aβ-treated rats.

Related Edges 3

• a(HBP:"C-30-27") directlyDecreases act(p(HGNC:KAT2B))
• p(FPLX:NFkappaB, pmod(Ac, Lys, 122)) positiveCorrelation act(p(HGNC:KAT2B))
• act(p(HGNC:KAT2B)) positiveCorrelation p(FPLX:NFkappaB, pmod(Ac, Lys, 122))

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