p(FPLX:UBE2) increases deg(a(MESH:Proteins))

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PubMed:29626319

Under physiological conditions, UPS, located in the cytosol and the nucleus in eukaryotic cells, as a major intracellular short-lived protein degradation system (Schwartz and Ciechanover 2009), mediates the clearance of misfolded or other abnormally modified proteins with the help of ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), ubiquitin ligase (E3), and the 26S proteasome for the sake of preventing the accumulation of toxic substances (Shang and Taylor 2011)

Related Edges 4

• a(MESH:"Ubiquitin-Protein Ligases") increases deg(a(MESH:Proteins))
• bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates deg(a(MESH:Proteins))
• p(HGNC:PSMD7) increases deg(a(MESH:Proteins))
• p(HGNC:UBA1) increases deg(a(MESH:Proteins))

MeSH

Cell Nucleus

MeSH

Cytosol

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