a(CHEBI:nicotine) increases bp(MESH:Neuroprotection)

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PubMed:19293145

It has been shown that the alpha7 receptors, but not the alpha3beta2 receptors, specifically trigger calcium release from intracellular stores by activating ryanodine receptors. Such a specific functional coupling of alpha7 receptors and ryanodine-sensitive stores may provide another site of therapeutic intervention. However, the sustained calcium rise seen in these cells upon prolonged nicotine administration, which is more likely to be of relevance to neuroprotection than short-term responses, is more dependent upon the activation of inositol 1,4,5-triphosphate receptors (Dajas-Bailador et al., 2002a), which are also a target for phosphorylation by FYN (Cui et al., 2004).

Related Edges 6

• a(CHEBI:"calcium(2+)") association act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors"))
• a(CHEBI:nicotine) increases a(CHEBI:"calcium(2+)")
• p(HGNC:CHRNA7) increases act(p(HGNCGENEFAMILY:"Ryanodine receptors"))
• p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(Ph))
• act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) association a(CHEBI:"calcium(2+)")
• act(p(HGNCGENEFAMILY:"Ryanodine receptors")) increases bp(GO:"cellular calcium ion homeostasis")

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