p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:H2afx)

View Subject View Object

PubMed:30126037

TauNFT mouse brains displayed significantly elevated histone γ-H2ax, a sensitive marker of both double-stranded DNA breaks and cellular senescence (Sedelnikova et al., 2004) (P = 0.0056; Figure 1d-e)

Related Edges 2

• p(MGI:H2afx) biomarkerFor bp(MESH:"DNA Breaks, Double-Stranded")
• p(MGI:H2afx) biomarkerFor bp(GO:"cellular senescence")

Confidence

Medium

MeSH

Neurons

MeSH

Alzheimer Disease

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---