a(GO:"neurofibrillary tangle") decreases bp(GO:"oxygen transport")

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PubMed:30126037

We found a significant genotype main effect for oxygen flux in both cortex and hippocampus, indicating that global respiratory capacity was impaired in NFT containing brain regions (P < 0.0001; Figure 3), an effect primarily driven by CI+CII respiration coupled to ATP production (cortex: P = 0.0034; hippocampus: P = 0.0215; Figure 2g and h, respectively), and uncoupled or maximum respiratory capacity (cortex: P = 0.0248; hippocampus: P = 0.0261; Figure 3g and h, respectively)

Related Edges 1

• bp(GO:"oxidative phosphorylation") decreases bp(GO:"oxygen transport")

Confidence

High

MeSH

Cerebral Cortex

MeSH

Hippocampus

MeSH

Alzheimer Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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