act(p(HGNC:RHOA)) negativeCorrelation a(MESH:"Dendritic Spines")

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PubMed:27796283

In contrast, much less is known about how RhoA is regulated by excitatory glutamate receptors. The Rho-GEF Lfc (also known as GEF-H1) is one notable link between RhoA activity and glutamate receptors18. Lfc is inhibited by AMPA receptors; Lfc and RhoA inhibition is implicated in spine maintenance10. RhoA hyperactivity can lead to spine loss and impaired synaptic function.

Related Edges 3

• a(MESH:"Dendritic Spines") negativeCorrelation act(p(HGNC:RHOA))
• complex(GO:"AMPA glutamate receptor complex") decreases act(p(HGNC:ARHGEF2))
• act(p(HGNC:ARHGEF2)) regulates a(MESH:"Dendritic Spines")

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