path(MESH:"Parkinson Disease") association p(HGNC:PRKN, var("?"))

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PubMed:30116051

First, autosomal recessive forms of early-onset PD are associated with mutations in PTEN-induced putative kinase protein 1 (PINK1) and the E3 ubiquitin-protein ligase parkin; these mutations lead to deficits in the mitophagic removal of damaged mitochondria 69,70 (BOX 2) .

Related Edges 5

• p(HGNC:PINK1, var("?")) association path(MESH:"Parkinson Disease")
• p(HGNC:PINK1, var("?")) decreases bp(GO:mitophagy)
• p(HGNC:PRKN, var("?")) association path(MESH:"Parkinson Disease")
• p(HGNC:PRKN, var("?")) decreases bp(GO:mitophagy)
• path(MESH:"Parkinson Disease") association p(HGNC:PINK1, var("?"))

MeSH

Parkinson Disease

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