a(PUBCHEM:135316034) increases p(HGNC:SOD1)

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PubMed:22020111

A likely explanation for the increased expression of GLRX2 (glutaredoxin 2) and NQO1 (NAD(P)H dehydrogenase, quinone 1) in colon carcinoma and of GLRX (glutaredoxin), HMOX1 (heme oxygenase-1), NQO1, and SOD1 (superoxide dismutase 1) in Alzheimer is that it represents an adaptive attempt to partially compensate for the increased level of oxidative stress associated with these diseases. These antioxidant genes are also upregulated by Protandim, which would provide additional antioxidant protection beyond that achieved by the ROS-dependent induction of these enzymes in the diseased tissues.

Related Edges 20

• a(PUBCHEM:135316034) increases p(HGNC:HMOX1)
• a(PUBCHEM:135316034) increases p(HGNC:GLRX2)
• a(PUBCHEM:135316034) increases p(HGNC:NQO1)
• a(PUBCHEM:135316034) increases p(HGNC:GLRX)
• bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Colorectal Neoplasms")
• bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:GLRX) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:GLRX2) positiveCorrelation path(MESH:"Colorectal Neoplasms")
• p(HGNC:HMOX1) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:NQO1) positiveCorrelation path(MESH:"Colorectal Neoplasms")
• p(HGNC:NQO1) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:SOD1) positiveCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:GLRX)
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:HMOX1)
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NQO1)
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SOD1)
• path(MESH:"Alzheimer Disease") positiveCorrelation bp(MESH:"Oxidative Stress")
• path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:GLRX2)
• path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:NQO1)
• path(MESH:"Colorectal Neoplasms") positiveCorrelation bp(MESH:"Oxidative Stress")

MeSH

Alzheimer Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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