a(CHEBI:sirolimus) decreases p(HGNC:MAPT)

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PubMed:29758300

Modulation of mTOR can influence the levels of tau, with upregulation increasing tau phosphorylation and accumulation by reducing autophagic clearance [87], and conversely, pharmacological treatment with rapamycin reducing tau levels and rescuing motor deficits in the Tau P301S mice [53]

Related Edges 5

• a(CHEBI:sirolimus) increases bp(GO:"motor behavior")
• bp(GO:autophagy) negativeCorrelation p(HGNC:MTOR)
• p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MTOR)
• p(HGNC:MTOR) positiveCorrelation p(HGNC:MAPT, pmod(Ph))
• p(HGNC:MTOR) negativeCorrelation bp(GO:autophagy)

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