act(p(HGNC:RAB5A)) increases a(CHEBI:"amyloid-beta")

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PubMed:22908190

Endocytic pathway up-regulation in AD stemming in part from pathological rab 5 activation generates higher levels of Ab (Mathews et al. 2002; Grbovic et al. 2003) that must be cleared in part by lysosomes.

Related Edges 4

• a(CHEBI:"amyloid-beta") positiveCorrelation bp(GO:endocytosis)
• bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:"amyloid-beta"))
• bp(GO:endocytosis) positiveCorrelation a(CHEBI:"amyloid-beta")
• act(p(HGNC:RAB5A)) increases bp(GO:endocytosis)

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