p(HGNC:PRKAA1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262))

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PubMed:29758300

A recent study has demonstrated that activation of AMPKα1 enhances tau phosphorylation, while inhibition reduces tau phosphorylation at Ser-262, an epitope that is increased in early stages of AD, which promotes the autophagic degradation of tau [87]

Related Edges 4

• bp(GO:autophagy) increases deg(p(HGNC:MAPT))
• p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:MAPT, pmod(Ph, Ser, 262)) increases bp(GO:autophagy)
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))

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