act(p(HGNC:CHRNA7)) increases a(CHEBI:anandamide)

PubMed:19126755

There is evidence that anandamide is produced by postsynaptic neurons in response to elevated intracellular Ca2+ levels. For instance, concomitant activation of alpha7 nAChRs and NMDA receptors triggers the production of anandamine in postsynaptic neurons (448). Anandamine, then, functions as a retrograde messenger and regulates synaptic transmission by interacting with specific receptors in the presynaptic neurons/terminals (498).

Related Edges 3

• a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases a(CHEBI:anandamide)
• a(CHEBI:anandamide) regulates bp(GO:"chemical synaptic transmission, postsynaptic")
• act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases a(CHEBI:anandamide)

MeSH

Neurons

Text Location

Review

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