p(HGNC:MAPT) regulates bp(GO:"axonal transport")

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PubMed:24590577

NFTs are formed by accumulation of hyperphosphorylated tau protein[7, 8]. Tau is a microtubule-binding protein whose function is to stabilize microtubules and facilitate fast axonal transport. Once highly phosphorylated, tau dissociates from microtubules and is prone to aggregate, forming paired helical fi laments that aggregate into NFTs

Related Edges 2

• a(HBP:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles")
• p(HGNC:MAPT) regulates bp(GO:"microtubule anchoring")

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