act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 370))

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PubMed:20869593

Incubation with p300, not pCAF, led to tau acetylation, while both p300 and pCAF were active in transferring acetyl groups to histones as expected (Figure 1A). A few putative acetylated lysines were in the N- and C- terminal regions; 13 were in microtubule-binding domains (Figure 1B and Table-S1). Putative acetylated N-terminal lysines (e.g., lysines 163, 174, and 180) appeared to be acetylated in all MS analyses. Those in the microtubule-binding domains appeared to be acetylated in a subset of MS analyses, suggesting variable acetylation at these sites in vitro.

Related Edges 17

• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 163))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 174))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 180))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 254))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 274))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 280))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 281))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 290))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 298))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 317))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 321))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 331))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 352))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 369))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 383))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 385))
• act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 395))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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