path(MESH:"Alzheimer Disease") increases p(HGNC:IL6R)

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PubMed:22020111

In Alzheimer disease, 66 genes were identified that are also modulated by Protandim at the gene expression level. Of these 66 genes, the first 43 of them (65%) were regulated by Protandim in the opposing direction to that taken by the Alzheimer disease process. The beneficial effect of Protandim is further supported by the fact that of the 10 gene products currently targeted by drug therapies, eight of them are modulated by Protandim in the same direction that is proposed to be beneficial and caused by the drug.

Related Edges 131

• a(PUBCHEM:135316034) increases p(HGNC:NFE2L2)
• a(PUBCHEM:135316034) increases p(HGNC:HMOX1)
• a(PUBCHEM:135316034) decreases p(HGNC:PTGS1)
• a(PUBCHEM:135316034) decreases p(HGNC:TUBB3)
• a(PUBCHEM:135316034) increases p(HGNC:NR3C1)
• a(PUBCHEM:135316034) increases p(HGNC:PPARA)
• a(PUBCHEM:135316034) increases p(HGNC:PTGS2)
• a(PUBCHEM:135316034) decreases p(HGNC:ACLY)
• a(PUBCHEM:135316034) decreases p(HGNC:TUBB)
• a(PUBCHEM:135316034) decreases p(HGNC:UNG)
• a(PUBCHEM:135316034) increases p(HGNC:NQO1)
• a(PUBCHEM:135316034) decreases p(HGNC:AGRN)
• a(PUBCHEM:135316034) decreases p(HGNC:ANP32A)
• a(PUBCHEM:135316034) decreases p(HGNC:BAX)
• a(PUBCHEM:135316034) decreases p(HGNC:BCHE)
• a(PUBCHEM:135316034) decreases p(HGNC:BGN)
• a(PUBCHEM:135316034) decreases p(HGNC:BRCA1)
• a(PUBCHEM:135316034) decreases p(HGNC:CADPS2)
• a(PUBCHEM:135316034) decreases p(HGNC:CAPN1)
• a(PUBCHEM:135316034) decreases p(HGNC:CCNB1)
• a(PUBCHEM:135316034) decreases p(HGNC:CDK1)
• a(PUBCHEM:135316034) decreases p(HGNC:CDK2)
• a(PUBCHEM:135316034) decreases p(HGNC:CDKN2A)
• a(PUBCHEM:135316034) decreases p(HGNC:CXCR4)
• a(PUBCHEM:135316034) decreases p(HGNC:EIF4EBP1)
• a(PUBCHEM:135316034) decreases p(HGNC:FOLH1)
• a(PUBCHEM:135316034) decreases p(HGNC:HOMER1)
• a(PUBCHEM:135316034) decreases p(HGNC:HRH1)
• a(PUBCHEM:135316034) decreases p(HGNC:IGF2)
• a(PUBCHEM:135316034) decreases p(HGNC:IGFBP2)
• a(PUBCHEM:135316034) decreases p(HGNC:LDLR)
• a(PUBCHEM:135316034) decreases p(HGNC:MAOA)
• a(PUBCHEM:135316034) decreases p(HGNC:NEFH)
• a(PUBCHEM:135316034) decreases p(HGNC:NPDC1)
• a(PUBCHEM:135316034) decreases p(HGNC:NRGN)
• a(PUBCHEM:135316034) decreases p(HGNC:PREP)
• a(PUBCHEM:135316034) decreases p(HGNC:PROS1)
• a(PUBCHEM:135316034) decreases p(HGNC:SELENBP1)
• a(PUBCHEM:135316034) decreases p(HGNC:TAGLN)
• a(PUBCHEM:135316034) decreases p(HGNC:TGFB1)
• a(PUBCHEM:135316034) decreases p(HGNC:VKORC1)
• a(PUBCHEM:135316034) increases p(HGNC:CANX)
• a(PUBCHEM:135316034) increases p(HGNC:GCNT2)
• a(PUBCHEM:135316034) increases p(HGNC:IDE)
• a(PUBCHEM:135316034) increases p(HGNC:MMP1)
• a(PUBCHEM:135316034) increases p(HGNC:SLC6A6)
• a(PUBCHEM:135316034) increases p(HGNC:SYVN1)
• a(PUBCHEM:135316034) increases p(HGNC:TSHZ1)
• a(PUBCHEM:135316034) increases p(HGNC:TXN)
• a(PUBCHEM:135316034) decreases p(HGNC:ATAD2)
• a(PUBCHEM:135316034) decreases p(HGNC:BECN1)
• a(PUBCHEM:135316034) decreases p(HGNC:DHCR24)
• a(PUBCHEM:135316034) decreases p(HGNC:FGF2)
• a(PUBCHEM:135316034) decreases p(HGNC:HTRA1)
• a(PUBCHEM:135316034) decreases p(HGNC:PRKCE)
• a(PUBCHEM:135316034) decreases p(HGNC:PRKDC)
• a(PUBCHEM:135316034) decreases p(HGNC:SCD)
• a(PUBCHEM:135316034) increases p(HGNC:ATP1A1)
• a(PUBCHEM:135316034) increases p(HGNC:CTSD)
• a(PUBCHEM:135316034) increases p(HGNC:GLRX)
• a(PUBCHEM:135316034) increases p(HGNC:IL6R)
• a(PUBCHEM:135316034) increases p(HGNC:NPTX1)
• a(PUBCHEM:135316034) increases p(HGNC:PHF1)
• a(PUBCHEM:135316034) increases p(HGNC:PRKCD)
• a(PUBCHEM:135316034) increases p(HGNC:RANBP9)
• a(PUBCHEM:135316034) increases p(HGNC:SOD1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:AGRN)
• path(MESH:"Alzheimer Disease") increases p(HGNC:ANP32A)
• path(MESH:"Alzheimer Disease") increases p(HGNC:BAX)
• path(MESH:"Alzheimer Disease") increases p(HGNC:BCHE)
• path(MESH:"Alzheimer Disease") increases p(HGNC:BGN)
• path(MESH:"Alzheimer Disease") increases p(HGNC:BRCA1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:CADPS2)
• path(MESH:"Alzheimer Disease") increases p(HGNC:CAPN1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:CCNB1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:CDK1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:CDK2)
• path(MESH:"Alzheimer Disease") increases p(HGNC:CDKN2A)
• path(MESH:"Alzheimer Disease") increases p(HGNC:CXCR4)
• path(MESH:"Alzheimer Disease") increases p(HGNC:EIF4EBP1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:FOLH1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:HOMER1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:HRH1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:IGF2)
• path(MESH:"Alzheimer Disease") increases p(HGNC:IGFBP2)
• path(MESH:"Alzheimer Disease") increases p(HGNC:LDLR)
• path(MESH:"Alzheimer Disease") increases p(HGNC:MAOA)
• path(MESH:"Alzheimer Disease") increases p(HGNC:NEFH)
• path(MESH:"Alzheimer Disease") increases p(HGNC:NPDC1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:NRGN)
• path(MESH:"Alzheimer Disease") increases p(HGNC:PREP)
• path(MESH:"Alzheimer Disease") increases p(HGNC:PROS1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:SELENBP1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:TAGLN)
• path(MESH:"Alzheimer Disease") increases p(HGNC:TGFB1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:TUBB3)
• path(MESH:"Alzheimer Disease") increases p(HGNC:VKORC1)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:CANX)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:GCNT2)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:IDE)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:MMP1)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:NFE2L2)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:NR3C1)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:PPARA)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:SLC6A6)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:SYVN1)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:TSHZ1)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:TXN)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:ACLY)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:ATAD2)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:BECN1)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:DHCR24)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:FGF2)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:HTRA1)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:PRKCE)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:PRKDC)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:SCD)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:TUBB)
• path(MESH:"Alzheimer Disease") decreases p(HGNC:UNG)
• path(MESH:"Alzheimer Disease") increases p(HGNC:ATP1A1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:CTSD)
• path(MESH:"Alzheimer Disease") increases p(HGNC:GLRX)
• path(MESH:"Alzheimer Disease") increases p(HGNC:HMOX1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:NPTX1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:NQO1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:PHF1)
• path(MESH:"Alzheimer Disease") increases p(HGNC:PRKCD)
• path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS2)
• path(MESH:"Alzheimer Disease") increases p(HGNC:RANBP9)
• path(MESH:"Alzheimer Disease") increases p(HGNC:SOD1)

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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