p(HBP:"CDK5R1 p25") positiveCorrelation p(HBP:"Tau epitope, AT8")

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PubMed:27087442

We demonstrated that the treatment of cultured hippocampal neurons with 125 µM glutamate for 20 min induced the cleavage of p35 to produce the p25 fragment 6 h after glutamate treatment, and the maximal levels of p25 were detected at 12 h (Fig. 1A), which is consistent with a peak in tau hyperphosphorylation (AT8).

Related Edges 2

• a(CHEBI:"glutamate(1-)") increases p(HBP:"CDK5R1 p25")
• p(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"CDK5R1 p25")

Uberon

hippocampal formation

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