p(HGNC:GSK3B) positiveCorrelation bp(MESH:"Oxidative Stress")

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PubMed:24355211

Nuclear factor erythroid-2-related factor 2 (Nrf2) is a transcription factor known to increase the level of many antioxidants, including glutathione-S transferase (GST), and is negatively regulated by the activity of GSK-3β. Our results indicated the increased nuclear localization of Nrf2 and level of GST, suggesting the increased activity of the transcription factor as a result of GSK-3β suppression, consistent with the decreased oxidative stress observed. Consistent with the improved learning and memory, and consistent with GSK-3b being a tau kinase, we observed decreased tau phosphorylation in brain of GAO-treated SAMP8 mice compared to that of RAO-treated SAMP8 mice.

Related Edges 9

• bp(GO:learning) negativeCorrelation p(HGNC:GSK3B)
• bp(GO:memory) negativeCorrelation p(HGNC:GSK3B)
• bp(MESH:"Oxidative Stress") positiveCorrelation p(HGNC:GSK3B)
• p(HGNC:NFE2L2) increases p(ECCODE:"2.5.1.18")
• p(HGNC:GSK3B) decreases p(HGNC:NFE2L2)
• p(HGNC:GSK3B) negativeCorrelation bp(GO:learning)
• p(HGNC:GSK3B) negativeCorrelation bp(GO:memory)
• act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231))
• act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235))

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