a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft"))

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PubMed:18096814

A rapid but transient increase was found in the amount of fyn detected in DRMs on ADDL exposure for 2 min that was partially reduced after 10 min exposure. Mirroring the movement of fyn into the DRM, tau content of DRMs increased in response to ADDLs. To further test a putative association between fyn and tau levels in DRMs, we treated cells with 2-bromopalmitate, an inhibitor of protein palmitoylation, which is required for fyn’s localization in DRMs. This treatment resulted in a progressive reduction in both fyn and tau in DRMs, demonstrating that the association of tau with DRMs may be directly regulated by fyn (Supplemental Fig. 2).

Related Edges 8

• a(CHEBI:"2-bromohexadecanoic acid") decreases p(MGI:Fyn, pmod(Palm))
• a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Mapt)
• a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Fyn)
• a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft"))
• p(MGI:Fyn) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid")
• p(MGI:Fyn) regulates tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft"))
• p(MGI:Fyn, pmod(Palm)) increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft"))
• p(MGI:Mapt) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid")

MeSH

Hippocampus

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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