a(HBP:"8-nitro-cGMP") decreases a(HBP:"Tau oligomers")

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PubMed:27601475

Tau contains cysteine residues in the microtubule binding region following alternative splicing of exon 10, and formation of intermolecular cysteine disulfide bonds accelerates tau aggregation. 8-Nitro-cGMP (novel second messenger of NO) exposure induced S-guanylation of tau both in vitro and in tau-overexpressed HEK293T cells. S-guanylated tau inhibited heparin-induced tau aggregation (thioflavin T). S-guanylated tau could not form tau granules and fibrils (AFM) inhibited at the step of tau oligomer formation. In P301L tau-expressing Neuro2A cells, 8-nitro-cGMP reduced the amount of sarcosyl-insoluble tau. NO-linked chemical modification on cysteine residues of tau could block tau aggregation

Related Edges 4

• a(CHEBI:"nitric oxide") positiveCorrelation a(HBP:"8-nitro-cGMP")
• a(CHEBI:heparin) increases p(HBP:"Tau aggregates")
• a(HBP:"8-nitro-cGMP") positiveCorrelation a(CHEBI:"nitric oxide")
• act(p(ECCODE:"1.14.13.39")) directlyIncreases a(CHEBI:"nitric oxide")

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