complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Alzheimer Disease")

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PubMed:17009926

Although Aβ peptides negatively alter the cholinergic system at multiple sites, including ACh synthesis, ACh release, and muscarinic receptors (157), the discovery that Aβ1−42 binds to α7 nAChRs with high affinity suggested the potential for a causal role of nAChRs in AD (159, 160).

Related Edges 4

• a(CHEBI:"amyloid-beta") decreases a(CHEBI:acetylcholine)
• a(CHEBI:"amyloid-beta") decreases sec(a(CHEBI:acetylcholine))
• a(CHEBI:"amyloid-beta") decreases act(p(FPLX:CHRM))
• path(MESH:"Alzheimer Disease") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7))

MeSH

Alzheimer Disease

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