p(HGNC:MAPT, pmod(Ac, Lys, 174)) negativeCorrelation act(p(HGNC:SIRT1))

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PubMed:29540553

SIRT1 deficiency exacerbates premature mortality, synapse loss, and behavioral disinhibition in tauP301S TG mice of both sexes. SIRT1 overexpression into the hippocampus reduces acetylated K174 tau and significantly attenuates the spread of tau pathology into anatomically connected brain regions of tauP301S transgenic mice of both sexes.

Related Edges 3

• a(HBP:"Pathological Tau Spreading") negativeCorrelation act(p(HGNC:SIRT1))
• act(p(HGNC:SIRT1)) negativeCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 174))
• act(p(HGNC:SIRT1)) negativeCorrelation a(HBP:"Pathological Tau Spreading")

Uberon

hippocampal formation

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