path(MESH:"Alzheimer Disease") association a(HBP:"alpha-4 beta-2 nAChR")

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PubMed:19293145

Genetic association studies investigating single nucleotide polymorphisms point to roles for cholinergic signaling components such as the synthetic enzyme ChAT, the inactivating enzyme AChE, and alpha4beta2 nAChRs in AD (Cook et al., 2004, 2005; Vasto et al., 2006). The most vulnerable neurons in AD seem to be those expressing high levels of nAChRs, particularly those containing the alpha7 subunit (D’Andrea and Nagele, 2006), and the numbers of nAChRs as well as some of their associated proteins change in AD (Martin-Ruiz et al., 1999; Gotti et al., 2006; Sabbagh et al., 2006).

Related Edges 7

• a(HBP:"alpha-4 beta-2 nAChR") association path(MESH:"Alzheimer Disease")
• p(HGNC:CHRNA7) association path(MESH:"Alzheimer Disease")
• g(HGNC:ACHE) association path(MESH:"Alzheimer Disease")
• g(HGNC:CHAT) association path(MESH:"Alzheimer Disease")
• path(MESH:"Alzheimer Disease") association g(HGNC:CHAT)
• path(MESH:"Alzheimer Disease") association g(HGNC:ACHE)
• path(MESH:"Alzheimer Disease") association p(HGNC:CHRNA7)

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