path(MESH:D003071) association g(HGNC:NTRK3)

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PubMed:18986241

These studies have demonstrated a significant downregulation of trkA, trkB and trkC gene expression during the development of AD [7]. An intermediate reduction was observed in MCI, with the greatest decrement in mild AD compared to aged controls. Moreover, two separate expressed sequence tag (EST) cDNAs for each trk gene (e.g., ESTs targeted to the extracellular domain [ECD] and tyrosine kinase [TK]) domains were downregulated. By contrast, there was a lack of regulation of p75NTR expression [7] in CBF neurons. A ‘step down’ dysregulation of trk expression may, in part, underlie CBF neuron demise associated with the clinical presentation of AD. Supporting this concept is the finding that trk downregulation is associated with measures of cognitive decline [7,14]

Related Edges 9

• g(HGNC:NTRK1) association path(MESH:D003071)
• g(HGNC:NTRK2) association path(MESH:D003071)
• g(HGNC:NTRK3) association path(MESH:D003071)
• path(MESH:D000544) decreases g(HGNC:NTRK1)
• path(MESH:D000544) decreases g(HGNC:NTRK2)
• path(MESH:D000544) decreases g(HGNC:NTRK3)
• path(MESH:D000544) increases g(HGNC:NGFR)
• path(MESH:D003071) association g(HGNC:NTRK1)
• path(MESH:D003071) association g(HGNC:NTRK2)

MeSH

Basal Forebrain

MeSH

Cholinergic Neurons

MeSH

Cognitive Dysfunction

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