a(MESH:"talsaclidine fumarate") decreases a(CHEBI:"amyloid-beta")

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PubMed:24590577

Another M1 mAChR-selective agonist, talsaclidine, enhances nonamyloidogenic processing of APP, resulting in increased sAPPalpha release from both a transfected human astrocytoma cell line and rat brain slices in a dose-dependent manner, as well as significantly decreasing CSF Abeta in AD patients[111]. However, talsaclidine at high doses had several side-effects such as sweating and salivation

Related Edges 3

• a(MESH:"talsaclidine fumarate") increases a(HBP:"sAPP-alpha")
• a(MESH:"talsaclidine fumarate") increases path(MESH:Sweating)
• a(MESH:"talsaclidine fumarate") increases path(MESH:Salivation)

MeSH

Cerebrospinal Fluid

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