act(p(HGNC:STUB1)) increases deg(p(HGNC:MAPT))

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PubMed:25031639

In particular, previous studies have demonstrated that the tau ubiquitin ligase, CHIP, is unable to bind and ubiquitinate tau species phosphorylated by Par-1/MARK2 on the 12E8 epitope (S262/356) [33], a p-tau species that is also resistant to degradation upon treatment with Hsp90 inhibitors [32,33]. Tau phosphorylated at the PHF1 epitope (S396/404) is still susceptible to degradation following Hsp90 inhibition and actually exhibits an enhanced interaction with Hsp90

Related Edges 5

• a(HBP:"Tau epitope, 12E8") negativeCorrelation act(p(HGNC:STUB1))
• a(HBP:"Tau epitope, PHF1") positiveCorrelation deg(p(HGNC:MAPT))
• deg(p(HGNC:MAPT)) positiveCorrelation a(HBP:"Tau epitope, PHF1")
• p(HGNC:MARK2) increases a(HBP:"Tau epitope, 12E8")
• act(p(HGNC:STUB1)) negativeCorrelation a(HBP:"Tau epitope, 12E8")

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