bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7)

PubMed:19721446

in the cerebral cortex, the massive reduction in nAChRs in Alzheimer’s disease128–130 involves predominantly the alpha4beta2 subtype, sparing the alpha7 subtype131. By contrast, in the hippocampus, a loss of alpha7 nAChRs seems to predominate and to correlate with the progressive loss of cognitive function132–136.

Related Edges 2

• p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition)
• path(MESH:"Alzheimer Disease") decreases p(HBP:"alpha-4 beta-2 nAChR")

MeSH

Hippocampus

MeSH

Alzheimer Disease

Text Location

Review

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