p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202))

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PubMed:8282104

The diagnostic antibodies AT8, TAU-1, SM131, SM134, and SM133 react to phosphorylation similarly as with MAPK and GSK-3, indicating that SP motifs before the repeat region (S199 and/or S202, S235) and after the repeats (S396, S404) become phosphorylated (Fig. 2,-2,); note that AT8, SMUl, and SM134 react with PHFs where the epitopes containing SP motifs are phosphorylated, while TAU-1 and SM133 react with normal tau where the epitopes are not phosphorylated

Related Edges 4

• p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199))
• p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235))
• p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396))
• p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404))

Confidence

High

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