a(CHEBI:"kynurenic acid") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))

PubMed:19126755

Of note is that in both of these catastrophic disorders, reduced nAChR activity/expression is accompanied by increased levels of kynurenic acid (KYNA), a tryptophan metabolite that in the brain is primarily produced and released by astrocytes (244, 419).

Related Edges 2

• a(MESH:Astrocytes) increases a(CHEBI:"kynurenic acid")
• act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation a(CHEBI:"kynurenic acid")

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