complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(FPLX:GST)

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PubMed:24563850

Oxidative stress abrogates the Keap1-mediated degradation of Nrf2 which in turn accumulates in the nucleus where it heterodimerizes with a small musculoapo- neurotic fibrosarcoma (Maf) protein on antioxidant response elements (AREs) to stimulate the expression of a wide arrays of phase II and antioxidant enzymes including NAD(P)H quinone oxidoreductase 1 (Nqo1), heme oxygenase 1 (Hmox1), glutamane- cysteine ligase (GCL) and glutathione S transferases (GSTs) [84,85,87,88].

Related Edges 6

• bp(GO:"response to oxidative stress") decreases act(p(HGNC:KEAP1))
• bp(GO:"response to oxidative stress") increases p(HGNC:NFE2L2)
• complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:NQO1)
• complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:HMOX1)
• complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:GCLC)
• act(p(HGNC:KEAP1)) increases deg(p(HGNC:NFE2L2))

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