p(FPLX:PI3K) increases act(a(CHEBI:nicotine))

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PubMed:19293145

The neuroprotective effects of nicotine are blocked by inhibitors of either PI3K or SRC family kinases, and nicotine evokes an increase in levels of phosphorylated AKT, B-cell chronic lymphocytic leukemia/lymphoma (BCL2), and BCL-2-like protein (Shimohama and Kihara, 2001), which are further downstream in the PI3K/AKT pathway (Fig. 3).

Related Edges 5

• act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection)
• act(a(CHEBI:nicotine)) increases p(FPLX:AKT, pmod(Ph))
• act(a(CHEBI:nicotine)) increases p(HGNC:BCL2)
• act(a(CHEBI:nicotine)) increases p(HGNC:BCL2L1)
• p(FPLX:SRC) increases act(a(CHEBI:nicotine))

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