p(HGNC:MAPT, pmod(Ph)) association p(HGNC:FYN)

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PubMed:19293145

FYN expression is increased in brains from patients with AD, specifically in a subset of neurons with elevated hyperphosphorylated tau protein (Shirazi and Wood, 1993), but it is not known whether this increase in FYN contributes to hyperphosphorylation of tau or is a protective response to it. In extracts of human brains from patients with AD, soluble FYN increases with cognitive score and synaptophysin levels and inversely with the tangle count, suggestive of a pro-cognitive role for FYN (Ho et al., 2005).

Related Edges 3

• p(HGNC:FYN) association p(HGNC:MAPT, pmod(Ph))
• p(HGNC:FYN) increases bp(GO:cognition)
• path(MESH:"Alzheimer Disease") increases p(HGNC:FYN)

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