a(HBP:"Tau epitope, 12E8") positiveCorrelation act(p(HGNC:HDAC6))

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PubMed:25031639

We demonstrate that elevated HDAC6 activity increases phosphorylation of tau at the 12E8 epitope (pS262/356), a phospho-epitope present within the KXGS motifs of tau’s microtubule-binding domain. The phosphorylation of KXGS motifs within tau by the kinase Par-1/MARK2 is required for tau proteotoxicity in Drosophila [29], observed at very early stages of NFT formation in AD brain [30], and appears to prime tau for subsequent phosphorylation events

Related Edges 2

• p(HBP:"KXGS motif") increases a(GO:"neurofibrillary tangle")
• act(p(HGNC:HDAC6)) positiveCorrelation a(HBP:"Tau epitope, 12E8")

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