p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph))

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PubMed:24027553

Mice in which the critical autophagy gene Atg7 is knocked out in forebrain neurons develop age-dependent neurodegeneration with accumulation of phosphorylated tau within intracellular inclusions (99). These inclusions specifically contained tau phosphorylated at AT8, AT100, and TG3 epitopes, but not PHF1. Significantly, if tau was also knocked out in these autophagy-deficient mice, neurodegeneration was reduced (99).

Related Edges 5

• p(MGI:Atg7) decreases path(HBP:Neurodegeneration)
• p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))
• p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
• p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Thr, 231))
• p(MGI:Mapt, pmod(Ph)) increases path(HBP:Neurodegeneration)

MeSH

Neurons

Text Location

Review

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