p(HGNC:CHRM4) decreases act(p(HGNC:DRD1))

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PubMed:24590577

M4 mAChR is also involved in the pathology of Parkinson’s disease, which is associated with the loss of dopaminergic neurons projecting to the striatum and an imbalance between cholinergic and dopaminergic systems. In the corpus striatum, M4 mAChR is closely co-localized with dopamine receptors on striatal-projecting neurons and the striatal M4 mAChR inhibits dopamine D1 receptor function. Mice lacking M4 mAChR show increased locomotor activity and enhanced dopamine D1 receptor-mediated effects[55]. Consequently, selective M4 mAChR antagonists, such as benzoxazines, have been developed for the treatment of Parkinson’s disease

Related Edges 6

• a(CHEBI:benzoxazine) decreases path(MESH:"Parkinson Disease")
• p(HGNC:CHRM4) association path(MESH:"Parkinson Disease")
• p(MGI:Chrm4) decreases bp(GO:"locomotor rhythm")
• p(MGI:Chrm4) decreases act(p(MGI:Drd1))
• path(MESH:"Parkinson Disease") association p(HGNC:CHRM4)
• path(MESH:"Parkinson Disease") decreases act(a(MESH:"Dopaminergic Neurons"))

MeSH

Corpus Striatum

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