act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B))

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PubMed:24590577

In addition to inhibiting Abeta generation, activation of M1 mAChR counteracts Abeta-induced neurotoxicity through the Wnt signaling pathway, as Abeta impairs the Wnt pathway and M1 mAChR stimulation inactivates GSK-3beta via PKC activation, stabilizes beta-catenin, and induces the expression of Wnt-targeting genes engrailed and cyclin-D1 for neuron survival

Related Edges 5

• bp(GO:"Wnt signaling pathway") decreases bp(HBP:neurotoxicity)
• act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC))
• act(p(HGNC:CHRM1)) increases bp(HBP:neurotoxicity)
• act(p(HGNC:CHRM1)) increases bp(GO:"Wnt signaling pathway")
• act(p(FPLX:PKC)) decreases act(p(HGNC:GSK3B))

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