a(CHEBI:acetylcholine) decreases path(MESH:"Heart Rate")

PubMed:19126755

From the time of its discovery in 1914 by Henry H. Dale (109) and Otto Loewi (283) (the two shared the Nobel Prize in Physiology and Medicine in 1936) as an agent that decreases heart rate, ACh was recognized as an endogenous signaling compound, synthesized from choline and acetyl-CoA, through the action of choline acetyltransferase, that alters cell function.

Related Edges 3

• a(CHEBI:acetylcholine) association bp(GO:signaling)
• bp(GO:signaling) association a(CHEBI:acetylcholine)
• act(p(HGNC:CHAT)) directlyIncreases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine)))

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