act(p(MGI:Chrm1)) decreases path(MESH:"Plaque, Amyloid")

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PubMed:24590577

though there are contradictory findings showing that the alpha-secretase-mediated APP processing via M1 mAChR stimulation is not modulated by the ERK1/MEK cascade[71]. On the other hand, loss of M1 mAChR increases amyloidogenic APP processing in neurons and promotes brain Abeta plaque pathology in a mouse model of AD

Related Edges 2

• act(p(HGNC:CHRM1)) causesNoChange bp(GO:"ERK1 and ERK2 cascade")
• act(p(MGI:Chrm1)) decreases bp(HBP:"APP processing")

MeSH

Alzheimer Disease

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