p(HGNC:CHRM1) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"))

PubMed:24511233

M1 mAChRs have been demonstrated to potentiate NMDA-receptor signaling in the hippocampus and cortex,48,49 brain areas intimately associated with learning and memory. In addition, M1 KO mice displayed reduced hippocampal long-term potentiation, a mechanism heavily implicated in learning and memory. Behaviorally, M1 KO animals display deficits in several medial prefrontal cortex-dependent cognitive tasks, including non-matching-to- sample, win-shift radial arm maze, and social discrimination tasks.

Related Edges 13

• a(MESH:"Cerebral Cortex") association bp(GO:learning)
• a(MESH:"Cerebral Cortex") association bp(GO:memory)
• a(MESH:Hippocampus) association bp(GO:learning)
• a(MESH:Hippocampus) association bp(GO:memory)
• bp(GO:"long-term synaptic potentiation") association bp(GO:learning)
• bp(GO:"long-term synaptic potentiation") association bp(GO:memory)
• bp(GO:learning) association a(MESH:Hippocampus)
• bp(GO:learning) association a(MESH:"Cerebral Cortex")
• bp(GO:memory) association a(MESH:"Cerebral Cortex")
• bp(GO:learning) association bp(GO:"long-term synaptic potentiation")
• bp(GO:memory) association a(MESH:Hippocampus)
• bp(GO:memory) association bp(GO:"long-term synaptic potentiation")
• p(HGNC:CHRM1) increases bp(GO:"long-term synaptic potentiation")

MeSH

Cerebral Cortex

MeSH

Hippocampus

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