p(FPLX:mTORC1) decreases bp(GO:autophagy)

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PubMed:23528736

The mammalian target of rapamycin (mTOR) kinase negatively modulates autophagy by phosphorylating Atg1, an autophagy initiating factor, while adenosine monophosphate-activated protein kinase (AMPK), a major sensor for the cellular energy status, activates autophagy through inhibiting mTOR signaling as well as by direct phosphorylation of Atg1 (Egan et al., 2011; Kim et al., 2011). Increased mTOR activity results in autophagy downregulation and tau accumulation.

Related Edges 6

• p(FPLX:AMPK) increases bp(GO:autophagy)
• p(FPLX:AMPK) decreases act(p(FPLX:mTORC1))
• p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph))
• act(p(FPLX:mTORC1), ma(kin)) increases p(HGNC:ULK1, pmod(Ph))
• act(p(FPLX:mTORC1)) increases p(HGNC:MAPT)
• p(HGNC:ULK1) increases bp(GO:autophagy)

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