a(CHEBI:"amyloid-beta") decreases a(GO:lysosome)

View Subject View Object

PubMed:24561250

Phagocytosis and subsequent lysosomal damage trigger by Aβ initiate the activation of the NLRP3 inflammasome in the microglia (Halle et al., 2008)

Related Edges 3

• a(CHEBI:"amyloid-beta") increases bp(GO:phagocytosis)
• a(GO:lysosome) decreases act(complex(GO:"NLRP3 inflammasome complex"))
• bp(GO:phagocytosis) increases act(complex(GO:"NLRP3 inflammasome complex"))

Cell Ontology (CL)

microglial cell

Confidence

High

NeuroMMSigDB

Amyloidogenic subgraph

NeuroMMSigDB

Endosomal lysosomal subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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