a(CHEBI:nicotine) increases a(CHEBI:acetylcholine)

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PubMed:19293145

It is now well established that exposure to nicotine results in increased expression of nAChRs in brain and in cultured cells (for review, see Gentry and Lukas, 2002). Exposure of human neuroblastoma SH-SY5Y cells (which express ganglionic alpha7 and alpha3* nAChRs), human TE671/RD cells, or mouse BC3H-1 cells (which express muscle-type nAChRs) to nicotine for up to 120 h induces a dose- and time-dependent increase in surface ACh and alpha-bungarotoxin (alpha-BTX) binding not attributable to changes in mRNA levels (Ke et al., 1998).

Related Edges 2

• a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
• a(CHEBI:nicotine) increases complex(a(MESH:Bungarotoxins), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))

Experimental Factor Ontology (EFO)

SH-SY5Y

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