a(MESH:D002800) decreases path(MESH:D000544)

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PubMed:18986241

Notably, reports that physostigmine and oral anticholinesterases have beneficial effects for patients with AD suggest that the CBF system is somewhat preserved during the progression of dementia, despite well-documented loss of cholinergic biosynthetic machinery (including ChAT and AChE enzyme deficits) in patients with this disease. Interestingly, recent studies have shown that ChAT activity, which results in acetylcholine (ACh) synthesis, is preserved in the neocortex of people with MCI [18,19].

Related Edges 5

• a(CHEBI:physostigmine) decreases path(MESH:D000544)
• a(MESH:D059329) association path(MESH:D003704)
• act(p(HGNC:CHAT)) directlyIncreases a(CHEBI:acetylcholine)
• path(MESH:D003704) association a(MESH:D059329)
• path(MESH:D060825) causesNoChange act(p(HGNC:CHAT))

Disease Ontology (DO)

Alzheimer's disease

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