p(HGNC:ATF4) increases p(HGNC:DDIT3)

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PubMed:25784053

Under these conditions, ATF4 mRNA is preferentially translated, leading to selective expression of the proapoptotic TF CHOP, which elicits apoptosis if ER stress is not resolved, presumably to ensure that irreversibly damaged cells are removed from the population.

Related Edges 1

• p(HGNC:DDIT3) increases bp(GO:"apoptotic process")

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